Fibronectin Adhesion-promoting Peptide TFA(Synonyms: Heparin Binding Peptide TFA)

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Fibronectin Adhesion-promoting Peptide TFA;(Synonyms: Heparin Binding Peptide TFA)

Fibronectin Adhesion-promoting Peptide TFA (Heparin Binding Peptide TFA) 是一种肝素结合氨基酸序列，这段序列存在于纤连蛋白 C-端的肝素结合域中。Fibronectin Adhesion-promoting Peptide TFA 促进间充质干细胞 (MSC) 球状体组装成更大的聚集体。Fibronectin Adhesion-promoting Peptide TFA 通过与细胞的肝素结合区反应直接促进内皮细胞的粘附、扩散和迁移。

Fibronectin Adhesion-promoting Peptide TFAamp;;(Synonyms: Heparin Binding Peptide TFA)

Fibronectin Adhesion-promoting Peptide TFA Chemical Structure

规格 是否有货
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Fibronectin Adhesion-promoting Peptide TFA 的其他形式现货产品:

Fibronectin Adhesion-promoting Peptide

生物活性

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells[1][2][3].

体外研究
(In Vitro)

GRGDS and Fibronectin Adhesion-promoting Peptide TFA (Heparin Binding Peptide TFA: WQPPRARI) micropatterns increase the endothelialisation of prosthetic materials in vitro. Fibronectin Adhesion-promoting Peptide also enhances haptotactic cell migration. The anti-apoptotic effects of fibronectin require the presence of the WQPPRARI sequence, which may be due to synergistic survival signals mediated by this sequence and by the RGD motif[1].
RDGS and Fibronectin Adhesion-promoting Peptide TFA promote cell adhesion through different activation pathways that induce different forms of adhesion which can be highlighted through the analysis of focal and fibrillar contacts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1137.22

Formula

C49H75F3N16O12
Sequence

Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile
Sequence Shortening

WQPPRARI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90.

    [2]. Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59.

    [3]. Lei J, Murphy WL, et al. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. Bioconjug Chem. 2018 Apr 18;29(4):878-884.