GIP (1-30) amide,human

GIP (1-30) amide,human;

GIP (1-30) amide,human 是葡萄糖依赖性促胰岛素多肽 (GIP) 片段。葡萄糖依赖性促胰岛素多肽是一种肠降血糖素激素,可刺激胰岛素分泌并减少餐后血糖波动。GIP (1-30) amide,human 在 10-9-10-6 M 范围内剂量依赖性地促进胰岛素分泌。

GIP (1-30) amide,humanamp;;

GIP (1-30) amide,human Chemical Structure

CAS No. : 198624-01-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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GIP (1-30) amide,human 的其他形式现货产品:

GIP (1-30) amide,human acetate

生物活性

GIP (1-30) amide,human is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide,human dose-dependently promotes insulin secretion over the range 10-9-10-6 M[1].

体外研究
(In Vitro)

The glucose-dependent action of Glucose-dependent insulinotropic polypeptide (GIP) on pancreatic β-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. In a 50% aqueous trifluoroethanol solvent, GIP(1-30) amide has an α-helical structural region from F6 to A28. The structures calculated for GIP(1-30) amide remain within one family of conformations and the level of agreement between the structures demonstrated the ordered arrangement[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3531.94

Formula

C162H240N40O47S

CAS 号

198624-01-0

Sequence

Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-NH2

Sequence Shortening

YAEGTFISDYSIAMDKIHQQDFVNWLLAQK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Alaña I, et al. NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide. Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6.