GR 64349

发表于2023年11月12日由Whatman官网

GR 64349;

GR 64349 是有效的、高度选择性的神经激肽 2 (NK₂) 受体的肽类拮抗剂，其在大鼠结肠中测得的EC₅₀ 值为 3.7 nM。GR 64349 对 NK₁ 和NK₃ 受体的选择性要低1000 和 300 倍以上。

GR 64349amp;;

GR 64349 Chemical Structure

CAS No. : 137593-52-3

规格		是否有货
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生物活性	GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively^[1]^[2].
分子量	921.11
Formula	C₄₂H₆₈N₁₀O₁₁S
CAS 号	137593-52-3
Sequence Shortening	KDSFV{Aaa}LM-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294(1):147-54. [2]. M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35(22):4195-204.