Histone H3 (1-35)

发表于由

Histone H3 (1-35);

Histone H3 (1-35) 是含 35 个氨基酸的组蛋白 H3 肽片段。Histone H3 是参与真核细胞染色质结构的五个主要组蛋白之一。

Histone H3 (1-35)amp;;

Histone H3 (1-35) Chemical Structure

CAS No. : 135990-31-7

规格 是否有货
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Histone H3 (1-35) 的其他形式现货产品:

Histone H3 (1-35) (TFA)

生物活性

Histone H3 (1-35) is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells[1].

体外研究
(In Vitro)

Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3551.13

Formula

C149H269N55O45
CAS 号

135990-31-7
Sequence Shortening

ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Manoj Bhasin, et al. Recognition and classification of histones using support vector machine. J Comput Biol. Jan-Feb 2006;13(1):102-12.