β-Casomorphin, bovine TFA(Synonyms: β-Casomorphin-7 (bovine) (TFA) Bovine β-casomorphin-7 TFA)

发表于由

β-Casomorphin, bovine TFA;(Synonyms: β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA)

β-casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) 是阿片 (opioid) 活性的多肽，与阿片受体结合的 IC50 值为 14 μM。

β-Casomorphin, bovine TFAamp;;(Synonyms: β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA)

β-Casomorphin, bovine TFA Chemical Structure

规格 价格 是否有货
5 mg ￥800 询问价格 货期
10 mg ￥1400 询问价格 货期
25 mg ￥2900 询问价格 货期

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beta;-Casomorphin, bovine TFA 的其他形式现货产品:

beta;-Casomorphin, bovine

生物活性

β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].

IC50 Target

IC50: 14 μM (Opioid receptor)[1]
体外研究
(In Vitro)

β-Casomorphin, bovine TFA (0.1μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2].
β-Casomorphin, bovine TFA (0.1μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2].
β-Casomorphin, bovine TFA does not modify the expression of rMuc1, rMuc4, and rMuc5AC[2].
β-Casomorphin, bovine TFA (0.1μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley (SD) rats (200 g±10 g)[3]
Dosage: 7.5×10−6 mol/day/kg
Administration: Oral gavage; for 30 days
Result: Increased plasma insulin and decreased plasma glucagon of diabetic rats.

分子量

903.94

Formula

C43H56F3N7O11
Sequence

Tyr-Pro-Phe-Pro-Gly-Pro-Ile
Sequence Shortening

YPFPGPI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9.

    [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.

    [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.