[Arg14,Lys15]Nociceptin

发表于由

[Arg14,Lys15]Nociceptin;

[Arg14,Lys15]Nociceptin 是一种高效、选择性的 NOP (ORL1; OP4) 受体激动剂，EC50为 1 nM。[Arg14,Lys15]Nociceptin 对阿片受体具有较高的选择性，对 NOP、μ、δ 和 κ 受体的 IC50 值分别为 0.32、280、>10000 和 1500 nM。

[Arg14,Lys15]Nociceptinamp;;

[Arg14,Lys15]Nociceptin Chemical Structure

CAS No. : 236098-40-1

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生物活性

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively[1].

体外研究
(In Vitro)

[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1909.16

Formula

C82H137N31O22
CAS 号

236098-40-1
Sequence Shortening

FGGFTGARKSARKRKNQ
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498.

    [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.