Osteogenic Growth Peptide (10-14)(Synonyms: OGP(10-14) Historphin)

发表于由

Osteogenic Growth Peptide (10-14);(Synonyms: OGP(10-14); Historphin)

Osteogenic Growth Peptide (10-14) (OGP(10-14)), 是成骨生长肽 (OGP) C 端截短的五肽，保留了完整的 OGP 样活性。Osteogenic Growth Peptide (10-14) 与 OGP 受体结合并激活细胞内 Gi 蛋白激酶信号通路。Osteogenic Growth Peptide (10-14) 是一种有效的有丝分裂原和促成骨和造血因子。Osteogenic Growth Peptide (10-14) 是 Src 抑制剂。

Osteogenic Growth Peptide (10-14)amp;;(Synonyms: OGP(10-14); Historphin)

Osteogenic Growth Peptide (10-14) Chemical Structure

CAS No. : 105250-85-9

规格 价格 是否有货
1 mg ￥2500 询问价格 货期
5 mg ￥6300 询问价格 货期
10 mg ￥10500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].

体外研究
(In Vitro)

Osteogenic Growth Peptide (10-14) (OGP(10-14)) induces proliferation and differentiation in fibroblast and osteoblast cell lines[3].
Osteogenic Growth Peptide (10-14) induces TPO-primed M07-e cells differentiation through RhoA/TGFβ1/SFKs signalling pathway. In particular Historphin acts as a Src inhibitor, showing the same effects of PP2[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

499.52

Formula

C24H29N5O7
CAS 号

105250-85-9
Sequence Shortening

YGFGG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chen YC, et al. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). J Med Chem. 2002;45(8):1624-1632.

    [2]. Chen Z, et al. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Protein Pept Lett. 2009;16(9):1074-1080.

    [3]. Fazzi R, et al. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Leuk Res. 2002;26(1):19-27.

    [4]. Battolla B, et al. The small peptide OGP(10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Med Sci Monit. 2011;17(1):SC1-SC5.