RIPK1-IN-12

发表于由

RIPK1-IN-12;

RIPK1-IN-12 是一种有效的 RIPK1 抑制剂，RIPK1-IN-12 能抑制人和小鼠细胞的坏死性凋亡，EC50 值分别为 1.6 和 2.9 nM.

RIPK1-IN-12amp;;

RIPK1-IN-12 Chemical Structure

CAS No. : 2173556-92-6

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100 mg ; 询价 ;
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生物活性

RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].

IC50 Target

RIPK1[1]
体外研究
(In Vitro)

RIPK1-IN-12 (Compound 58; 24 hours) demonstrates potent anti-necroptotic activity (EC50=1.6 nM in HT-29 cells and EC50= 2.9 nM in L929 cells)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

450.55

Formula

C24H26N4O3S
CAS 号

2173556-92-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li Z, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022, 228:114036.