[D-Trp7,9,10]-Substance P

发表于由

[D-Trp7,9,10]-Substance P;

[D-Trp7,9,10]-Substance P 是 substance P 的类似物。Substance P 刺激 substance P 受体，但也通过烟碱乙酰胆碱受体抑制离子传导。

[D-Trp7,9,10]-Substance Pamp;;

[D-Trp7,9,10]-Substance P Chemical Structure

CAS No. : 89430-38-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

体外研究
(In Vitro)

Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibitS the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1588.88

Formula

FH2KNP2W3
CAS 号

89430-38-6
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2
Sequence Shortening

RPKPQQWFWWM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eardley D, et al. Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells. Eur J Pharmacol. 1985;114(1):101-104.

    [2]. Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243.