[D-Arg25]-Neuropeptide Y (human)

[D-Arg25]-Neuropeptide Y (human);

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是 Y1 受体的选择性激动剂。Neuropeptide Y (human) 和阿尔兹海默症相关,能够保护老鼠皮质神经元对抗淀粉样蛋白毒性。

[D-Arg25]-Neuropeptide Y (human)amp;;

[D-Arg25]-Neuropeptide Y (human) Chemical Structure

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生物活性

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y1 receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer’s disease (AD) and protects rat cortical neurons against β-Amyloid toxicity[1].

体外研究
(In Vitro)

[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4271.68

Formula

C189H285N55O57S

Sequence Shortening

YPSKPDNPGEDAPAEDMARYYSAL-{D-Arg}-HYINLITRQRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kilian Kuhn, et al. Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonists. zur Erlangung des Doktorgrades der Naturwissenschaften an der Fakultät für Chemie und Pharmazie der Universität Regensburg.

    [2]. Li-Ying Fu, et al. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004 Oct 6;24(40):8741-51.

    [3]. Ambikaipakan Balasubramaniam, et al. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr Pharm Des. 2003;9(15):1165-75.

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