Foxy-5

发表于由

Foxy-5;

Foxy-5 是 WNT5A 激动剂，是 WNT5A 的一个模拟肽，是 Wnt 家族的非经典成员。Foxy-5 可在不影响 β-catenin 激活的情况下触发胞浆游离钙信号传导，并可抑制上皮癌细胞的迁移和侵袭。Foxy-5 在原位小鼠模型中能有效降低 WNT5A 低表达的前列腺癌细胞的转移扩散。

Foxy-5amp;;

Foxy-5 Chemical Structure

CAS No. : 881188-51-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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Foxy-5 的其他形式现货产品:

Foxy-5 TFA

生物活性

Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2][3][4].

IC50 Target

WNT5A[2]
体内研究
(In Vivo)

Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1].
Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

694.77

Formula

C26H42N6O12S2
CAS 号

881188-51-8
Sequence Shortening

MDGCEL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418.

    [2]. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728.

    [3]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418.

    [4]. Kelsey R. Prostate cancer: Foxy-5 in prostate cancer model. Nat Rev Urol. 2017 Nov;14(11):638.

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