Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate(Synonyms: MOG (35-55) (acetate))

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate;(Synonyms: MOG (35-55) (acetate))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。还能诱导强效的 T细胞和 B 细胞反应，同时是高度脑源性的。

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetateamp;;(Synonyms: MOG (35-55) (acetate))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate Chemical Structure

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生物活性

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate induces strong T and B cell responses and is highly encephalitogenic[1][2][3].

体内研究
(In Vivo)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG) is a highly autoantigenic molecule capable of inducing severe demyelinating disease[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred female NOD/Lt (H-P’), C57BL/6 (H-2b), C57BL/10 (H-2′), DBAj2 (H-2d), BALB/c (H-2″), BALB/c (H-2b), C3H/HeJ (H-2k), BI0.Br (H-2k), BI0.S (H-2′), SJL/J (H-2′) and PL/J (H-2″) mice[2].
Dosage: 50 μg (100 μg total).
Administration: Injected in each hind footpad.
Result: Mice receiving 50 μg and 100 μg of peptide has more dramatic weight losses during the course of the disease than mice injected with 150 μg.

分子量

2642.00

Formula

C120H181N35O31S
Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ichikawa M, et al. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J Immunol. 1996 Jul 15;157(2):919-26.

    [2]. Slavin A, et al. Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity. 1998;28(2):109-20.

    [3]. Zhang GX, et al. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice. J Neuroimmunol. 2004 Mar;148(1-2):1-10.