YAP-TEAD-IN-1

YAP-TEAD-IN-1;

YAP-TEAD-IN-1 是 YAP–TEAD 相互作用的有效的竞争性肽类抑制剂 (IC50=25 nM)。YAP-TEAD-IN-1 是一种 17mer 的多肽,与 YAP (50-171) (Kd=40 nM) 相比,其与 TEAD1 的结合亲和力更高 (Kd=15 nM)。

YAP-TEAD-IN-1amp;;

YAP-TEAD-IN-1 Chemical Structure

CAS No. : 1659305-78-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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YAP-TEAD-IN-1 的其他形式现货产品:

YAP-TEAD-IN-1 TFA

生物活性

YAP-TEAD-IN-1 is a potent and competitive inhibitor of YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].

IC50 Target

IC50: 25 nM (YAP–TEAD interaction)[1]

体外研究
(In Vitro)

YAP-TEAD-IN-1 (peptide 17)(2 μM) is against endogenous YAP binding to GST-TEAD (1209-426) in a GST pull-down assay, the Kd of His-YAP1209-426 is determined to be 40 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2019.86

Formula

C93H144ClN23O21S2

CAS 号

1659305-78-8

Sequence Shortening

Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.