Albiglutide TFA

Albiglutide TFA; 纯度: 97.51%

Albiglutide TFA 是一种胰高血糖素样肽 GLP-1 模拟物,是长效 GLP-1 受体激动剂,用于研究研究 2 型糖尿病 (T2DM)。Albiglutide TFA 是由抗 DPP-4 的 GLP-1 二聚体与人白蛋白的基因融合产生的。

Albiglutide TFAamp;;

Albiglutide TFA Chemical Structure

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1 mg ¥1800 In-stock
5 mg ¥5250 In-stock
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Albiglutide TFA 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Albiglutide TFA, a glucagon-like peptide (GLP)-1 mimetic, is a long acting GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus (T2DM). Albiglutide TFA is generated by the genetic fusion of a DPP-4-resistant GLP-1 dimer to human albumin[1][2].

Clinical Trial

分子量

3397.63

Formula

C150H225F3N40O47

Sequence

His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Sequence Shortening

HGEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

参考文献
  • [1]. Matthews JE, et al. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes. J Clin Endocrinol Metab. 2008 Dec;93(12):4810-7.

    [2]. Blair HA, et al. Albiglutide: a review of its use in patients with type 2 diabetes mellitus. Drugs. 2015 Apr;75(6):651-63.