Calmodulin-Dependent Protein Kinase II(290-309) acetate

Calmodulin-Dependent Protein Kinase II(290-309) acetate; 纯度: 98.97%

Calmodulin-Dependent Protein Kinase II (290-309) acetate 是有效的 CaMK 拮抗剂, 抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的 IC50 值为52 nM。

Calmodulin-Dependent Protein Kinase II(290-309) acetateamp;;

Calmodulin-Dependent Protein Kinase II(290-309) acetate Chemical Structure

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Calmodulin-Dependent Protein Kinase II(290-309) acetate 相关产品

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  • Peptide Library

生物活性

Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II[1].

IC50 Target

IC50: 52 nM (calmodulin-dependent protein kinase II)[1].

体外研究
(In Vitro)

Peptide 290 to 309 is found to be a potent calmodulin antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase. Neither truncation from the amino terminus (peptide 296-309) nor extension in the carboxyl-terminal direction (peptide 294-319) markedly affects calmodulin binding, whereas shortening the peptide from the carboxyl terminus (peptide 290-302) or from both ends (peptide 295-304) results in the elimination of this activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2333.88

Formula

C105H189N31O26S

Sequence Shortening

LKKFNARRKLKGAILTTMLA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Payne ME, et al. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem. 1988 May 25;263(15):7190-5.