N-Acetyl-Ser-Asp-Lys-Pro TFA;(Synonyms: Ac-SDKP TFA)
N-Acetyl-Ser-Asp-Lys-Pro (TFA) 是来自骨髓的内源性四肽,是 ACE 的N-末端位点的特异性底物。
N-Acetyl-Ser-Asp-Lys-Pro TFA Chemical Structure
规格 | 价格 | 是否有货 | |
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1 mg | ¥500 | 询问价格 货期 | |
5 mg | ¥1100 | 询问价格 货期 | |
10 mg | ¥1750 | 询问价格 货期 | |
25 mg | ¥3800 | 询问价格 货期 |
* Please select Quantity before adding items.
N-Acetyl-Ser-Asp-Lys-Pro TFA 的其他形式现货产品:
生物活性 |
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE. |
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体外研究 (In Vitro) |
N-Acetyl-Ser-Asp-Lys-Pro is degraded specifically by ACE, and its plasma level rises substantially during ACE inhibitor therapy. Flow cytometry of rat cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro shows significant inhibition of the progression of cells from G0/G1 phase to S phase of the cell cycle. Moreover, phosphorylation and nuclear translocation of Smad2 is decreased in cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro[1]. N-acetyl-seryl-aspartyl-lysyl-proline appears to exert this function by blocking the action of a stem cell-specific proliferation stimulator and acts selectively on quiescent progenitors[2]. N-Acetyl-Ser-Asp-Lys-Pro inhibits collagenase expression and activation is associated with increased expression of TIMP-1 and TIMP-2. N-Acetyl-Ser-Asp-Lys-Pro normalizes the IL-1β-mediated increase in MMP-2 and MMP-9 activities and MMP-13 expression[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
N-Acetyl-Ser-Asp-Lys-Pro prevents hypertension-induced inflammatory cell infiltration, collagen deposition, nephrin downregulation and albuminuria, which could lead to renoprotection in hypertensive mice[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
601.53 |
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Formula |
C22H34F3N5O11 |
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Sequence |
Ac-Ser-Asp-Lys-Pro |
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Sequence Shortening |
Ac-SDKP |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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