SKF 100398(Synonyms: d(CH2)5Tyr(Et)VAVP)

发表于由

SKF 100398;(Synonyms: d(CH2)5Tyr(Et)VAVP)

SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物，能作为外源性和内源性 AVP 抗利尿作用的特异性拮抗剂。

SKF 100398amp;;(Synonyms: d(CH2)5Tyr(Et)VAVP)

SKF 100398 Chemical Structure

CAS No. : 77453-01-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].

体内研究
(In Vivo)

SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1].
SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g)[1]
Dosage: 8 μg/kg
Administration: Intravenous injection
Result: Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.).

分子量

1136.39

Formula

C53H77N13O11S2
CAS 号

77453-01-1
Sequence

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6)
Sequence Shortening

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-YFVNCPRG-NH2 (Disulfide bridge: 1-Cys6)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. S Ishikawa, et al. Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin. Am J Physiol. 1983 Nov;245(5 Pt 1):R713-9.