RFRP-1(human)

发表于由

RFRP-1(human); 纯度: 99.32%

RFRP-1(human) 是促性腺激素抑制激素 (GnIH) 的同系物。RFRP-1(human) 靶向人类促性腺激素释放激素 (GnRH) 神经元和促性腺激素，并有效抑制促性腺激素。RFRP-1(human) 是一种有效的神经肽 FF (NPFF) 受体激动剂，对 NPFF2 和 NPFF1 的 EC50 分别为 0.0011 nM 和 29 nM。

RFRP-1(human)amp;;

RFRP-1(human) Chemical Structure

CAS No. : 311309-25-8

规格 价格 是否有货 数量
5 mg ￥3100 In-stock
10 mg ￥5500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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RFRP-1(human) 相关产品

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生物活性

RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively[1][2][3].

体内研究
(In Vivo)

RFRP-1(human) rapidly and reversibly decreases shortening and relaxation in isolated mammalian cardiac myocytes in a dose dependent manner[2].
Intravenous injection of RFRP-1(human) in mice decreases heart rate, stroke volume, ejection fraction, and cardiac output[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1428.72

Formula

C67H101N19O14S
CAS 号

311309-25-8
Sequence Shortening

MPHSFANLPLRF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (69.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6999 mL 3.4996 mL 6.9993 mL
5 mM 0.1400 mL 0.6999 mL 1.3999 mL
10 mM 0.0700 mL 0.3500 mL 0.6999 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Takayoshi Ubuka, et al. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One. 2009 Dec 22;4(12):e8400.

    [2]. R Nichols, et al. Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides. 2010 Nov;31(11):2067-74.

    [3]. C Gouardères, et al. Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPgammaS binding. Neuropharmacology. 2007 Feb;52(2):376-86.