Substance P(1-7) TFA; 纯度: 99.86%
Substance P(1-7) TFA 是神经肽 P 物质 (SP) 的片段。Substance P(1-7) TFA 可对孤束核产生抑制和缓和作用。
Substance P(1-7) TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥1100 | In-stock | |
10 mg | ¥1800 | In-stock | |
25 mg | ¥3900 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Substance P(1-7) TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Neuronal Signaling Compound Library
- Peptidomimetic Library
- Endocrinology Compound Library
- Neurotransmitter Receptor Compound Library
- Peptide Library
生物活性 |
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius[1]. |
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体内研究 (In Vivo) |
Substance P(1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P(1-7) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P(1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1014.06 |
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Formula |
C43H66F3N13O12 |
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Sequence |
Arg-Pro-Lys-Pro-Gln-Gln-Phe |
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Sequence Shortening |
RPKPQQF |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
H2O : 50 mg/mL (49.31 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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Animal Administration [1][2] |
Rats[1] Sprague-Dawley male rats weighing 250-300 g are anaesthetized with halothane and placed in a stereotaxic frame. An injection cannula, conically shaped with a penetration tip diameter of approximately 0.15 mm is loared into the SNR. Saline (0.2 μL), SP (0.007-0.7 nmol) or Substance P(1-7) (0.01-1 nmol) is injected into the left substantia nigra, pars reticulata (SNR) and the rat is placed in a rotometer. The substances are injected in a total volume of 0.2 μL over a period of 1 min. A group of animals is sacrificed by decapitation 1 hour after the injection, their brains are immediately removed and tissue samples are taken from left and right striatum, globus pallidum (GP) and substantia nigra (SN). Samples are assayed for SP and SP(1-7)[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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