Abarelix;(Synonyms: 阿巴瑞克; R3827; PPI 149) 纯度: 96.27%
Abarelix (R3827) 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于研究前列腺癌。
Abarelix Chemical Structure
CAS No. : 183552-38-7
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥3894 | In-stock | |
5 mg | ¥1500 | In-stock | |
10 mg | ¥2500 | In-stock | |
25 mg | ¥5500 | In-stock | |
50 mg | ¥9500 | 询价 | |
100 mg | ; | 询价 | ; |
200 mg | ; | 询价 | ; |
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Abarelix 相关产品
bull;相关化合物库:
- FDA-Approved Drug Library Mini
生物活性 |
Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment. |
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体外研究 (In Vitro) |
Abarelix (30 and 300 µg/mL) causes significantly increased histamine release[1]. Abarelix is the first GnRH antagonist to be developed, and can produce rapid and sustained decreases in testosterone to castrate levels without the need for co-administration of an antiandrogen, and with a very low complication rate in the short term[2]. Abarelix demonstrates to promptly and substantially reduce follicle-stimulating hormone levels to lower than LHRH agonist. Abarelix does not cause a surge in serum testosterone that can precipitate a flare phenomenon or worsening of disease, particularly dangerous for patients with metastatic, symptomatic disease, and produces medical castration more quickly[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
1416.06 |
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Formula |
C72H95ClN14O14 |
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CAS 号 |
183552-38-7 |
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Sequence Shortening |
Ac-{d-2-Nal}-{d-4-Cpa}-{d-3-Pal}-S-{NMyr}-{d-Asp}-L-K(ipr)-P-{d-Ala}-NH2 |
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中文名称 |
阿巴瑞克 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 14.2 mg/mL (10.03 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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