PBP10 TFA

发表于由

PBP10 TFA; 纯度: 98.47%

PBP10 是一种甲酰基肽受体 2 (FPR2) 的细胞通透性和选择性的由 gelsolin 衍生的肽抑制剂，选择性优于对 FPR1 的。PBP10 是一种 N 端偶联罗丹明的10 个氨基酸的肽，对革兰氏阳性和革兰氏阴性菌具有杀菌活性，并且可以限制微生物诱导的炎症作用。

PBP10 TFAamp;;

PBP10 TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥4200 In-stock
10 mg ￥6700 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

PBP10 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Immunology/Inflammation Compound Library
  • Antibacterial Compound Library
  • Peptide Library

生物活性

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].

IC50 Target

IC50: formyl peptide receptor 2 (FPR2)[1]
分子量

1827.08

Formula

C86H128F3N24O17
Sequence

RhB-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
Sequence Shortening

RhB-QRLFQVKGRR-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 7.14 mg/mL (3.91 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5473 mL 2.7366 mL 5.4732 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17(1):22.

    [2]. C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem