Transdermal Peptide Disulfide TFA(Synonyms: TD 1 Disulfide(peptide) TFA)

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Transdermal Peptide Disulfide TFA;(Synonyms: TD 1 Disulfide(peptide) TFA) 纯度: 98.45%

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide Disulfide TFA 能够增强一些大分子在皮肤中的传递。

Transdermal Peptide Disulfide TFAamp;;(Synonyms: TD 1 Disulfide(peptide) TFA)

Transdermal Peptide Disulfide TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥800 In-stock
5 mg ￥1800 In-stock
10 mg ￥2800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Transdermal Peptide Disulfide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules[1].

体外研究
(In Vitro)

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1175.17

Formula

C42H65F3N14O18S2
Sequence Shortening

ACSSSPSKHCG (Disulfide bridge: Cys2-Cys10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (85.09 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8509 mL 4.2547 mL 8.5094 mL
5 mM 0.1702 mL 0.8509 mL 1.7019 mL
10 mM 0.0851 mL 0.4255 mL 0.8509 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.