Neuromedin N(Synonyms: Neuromedin N (rat, mouse, porcine, canine))

发表于由

Neuromedin N;(Synonyms: Neuromedin N (rat, mouse, porcine, canine)) 纯度: 99.49%

Neuromedin N 是大鼠多巴胺 D2 受体激动剂结合新纹状体膜的有效调节剂。

Neuromedin Namp;;(Synonyms: Neuromedin N (rat, mouse, porcine, canine))

Neuromedin N Chemical Structure

CAS No. : 92169-45-4

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥1559 In-stock
5 mg ￥950 In-stock
10 mg ￥1400 In-stock
25 mg ￥3000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Neuromedin N 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Peptidomimetic Library
  • Neurotransmitter Receptor Compound Library
  • Peptide Library

生物活性

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

IC50 Target

Dopamine D2 receptor[1].
体外研究
(In Vitro)

Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

745.95

Formula

C38H63N7O8
CAS 号

92169-45-4
Sequence

Lys-Ile-Pro-Tyr-Ile-Leu
Sequence Shortening

KIPYIL
中文名称

神经介素 N
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (67.03 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3406 mL 6.7029 mL 13.4057 mL
5 mM 0.2681 mL 1.3406 mL 2.6811 mL
10 mM 0.1341 mL 0.6703 mL 1.3406 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4.

    [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.