PLP (139-151)

发表于由

PLP (139-151); 纯度: 98.34%

PLP (139-151) 是髓鞘蛋白脂蛋白 (PLP) 139至151氨基酸片段。用于诱导实验性自身免疫性脑脊髓炎 (EAE)。

PLP (139-151)amp;;

PLP (139-151) Chemical Structure

CAS No. : 131334-43-5

规格 价格 是否有货 数量
1 mg ￥990 In-stock
5 mg ￥3900 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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PLP (139-151) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Animal Disease Model Inducer Library
  • Peptide Library

生物活性

PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

体外研究
(In Vitro)

Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28[2]. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1537.79

Formula

C72H104N20O16S
CAS 号

131334-43-5
Sequence

His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe
Sequence Shortening

HCLGKWLGHPDKF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (32.51 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6503 mL 3.2514 mL 6.5028 mL
5 mM 0.1301 mL 0.6503 mL 1.3006 mL
10 mM 0.0650 mL 0.3251 mL 0.6503 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kuchroo VK, et al. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59(5):305-12.

    [2]. Sobel RA, et al. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide ofmyelin proteolipid protein. J Neuropathol Exp Neurol. 1990 Sep;49(5):468-79.

    [3]. Bebo BF Jr, et al. Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res. 1996 Sep 15;45(6):680-9.