CRF, bovine TFA;(Synonyms: Corticotropin Releasing Factor bovine TFA) 纯度: 96.50%
CRF, bovine (TFA) 是一种有效的 CRF 受体激动剂,能够取代 [125I-Tyr]ovine CRF,Ki 值为 3.52 nM。
CRF, bovine TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
500 μg | ¥2160 | In-stock | |
1 mg | ¥3480 | In-stock | |
5 mg | ¥11880 | In-stock | |
10 mg | ; | 询价 | ; |
50 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
CRF, bovine TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. |
IC50 Target |
Ki: 3.52 nM (CRF receptor)[1]. |
||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8.70 for human CRF1, human CRF2 and rat CRF2α[2]. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||||||
分子量 |
4811.36 |
||||||||||||||||||||
Formula |
C208H341F3N60O65S |
||||||||||||||||||||
Sequence |
Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Asn-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2 |
||||||||||||||||||||
Sequence Shortening |
SQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIA-NH2 |
||||||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||||||
储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
||||||||||||||||||||
Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
|
||||||||||||||||||||
参考文献 |
|