[Sar9,Met(O2)11]-Substance P TFA

[Sar9,Met(O2)11]-Substance P TFA; 纯度: 99.68%

[Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽 NK1 受体激动剂。

[Sar9,Met(O2)11]-Substance P TFAamp;;

[Sar9,Met(O2)11]-Substance P TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥990 In-stock
5 mg ¥3900 In-stock
10 mg ¥6900 In-stock
25 mg ¥14000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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[Sar9,Met(O2)11]-Substance P TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist.

IC50 Target

NK1 receptor[1]

体外研究
(In Vitro)

[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1507.68

Formula

C66H101N18F3O17S

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{Sar}-Leu-Met[O2]-NH2

Sequence Shortening

RPKPQQFF-{Sar}-LM[O2]-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 100 mg/mL (66.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6633 mL 3.3164 mL 6.6327 mL
5 mM 0.1327 mL 0.6633 mL 1.3265 mL
10 mM 0.0663 mL 0.3316 mL 0.6633 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.