TAT-Gap19 TFA

TAT-Gap19 TFA; 纯度: 98.36%

TAT-Gap19 TFA 是一种 Cx 模拟肽,是一种特定的 connexin43 半通道 (Cx43 HC) 抑制剂。TAT-Gap19 TFA 不抑制相应的 Cx43 GJC。TAT-Gap19 TFA 可以透过血脑屏障,减轻小鼠的肝纤维化。

TAT-Gap19 TFAamp;;

TAT-Gap19 TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ¥2200 In-stock
10 mg ¥3700 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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TAT-Gap19 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice[1][2][3].

体内研究
(In Vivo)

A single injection of TAT-Gap19 TFA (i.v. via the tail vein; 55 mg/kg) produces significant immune signal in the brain 24 h later in 4 months old C57Bl6 male mice[1].
TAT-Gap19 TFA (1 mg/kg/day; an osmotic pump implanted in the peritoneal cavity; Two weeks) shows significantly decreased collagen deposition, as well as lowed amounts of α-SMA-positive cells area in mice subjected to treatment with 100-200 mg thioacetamide (TAA)/kg body weight for eight weeks[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2817.27

Formula

C121H213F3N46O28

Sequence Shortening

YGRKKRRQRRRKQIEIKKFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 100 mg/mL (35.50 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3550 mL 1.7748 mL 3.5495 mL
5 mM 0.0710 mL 0.3550 mL 0.7099 mL
10 mM 0.0355 mL 0.1775 mL 0.3550 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Verónica Abudara, et al. The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 2014 Oct 21;8:306.

    [2]. Sara Crespo Yanguas, et al. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018 Mar 12;19(3):817.

    [3]. Laura Walrave, et al. Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents. Glia. 2018 Aug;66(8):1788-1804.