G3-C12 TFA

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G3-C12 TFA; 纯度: 99.45%

G3-C12 (TFA) 是 galectin-3 结合肽，Kd 值为 88 nM，具有抗肿瘤活性。

G3-C12 TFAamp;;

G3-C12 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥900 In-stock
5 mg ￥2200 In-stock
10 mg ￥3300 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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G3-C12 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

G3-C12 (TFA) is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.

IC50 Target

Kd: 88 nM (Galectin-3)[1].
体外研究
(In Vitro)

G3-C12 (TFA) is a galectin-3 binding peptide, with high affinity (Kd) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 (TFA) bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1873.00

Formula

C74H115N23O23S2.C2HF3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : ≥ 50 mg/mL (26.70 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5339 mL 2.6695 mL 5.3390 mL
5 mM 0.1068 mL 0.5339 mL 1.0678 mL
10 mM 0.0534 mL 0.2670 mL 0.5339 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.