Parathyroid hormone (1-34) (rat)

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Parathyroid hormone (1-34) (rat); 纯度: 95.53%

Parathyroid hormone (1-34) (rat) 是甲状旁腺激素，可改善皮质和松质骨结构。

Parathyroid hormone (1-34) (rat)amp;;

Parathyroid hormone (1-34) (rat) Chemical Structure

CAS No. : 98614-76-7

规格 价格 是否有货 数量
1 mg ￥3200 In-stock
5 mg ￥9000 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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生物活性

Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure[1].

体内研究
(In Vivo)

PTH (80 μg/kg per day (hPTH), s.c., 4 weeks ) induces a ~35% recovery of this loss and a ~40% reversal of the associated decreases in trabecular number (Tb.N) and connectivity. PTH also causes a shift from single to double calcein-labeled trabecular surfaces, a significant enhancement in the mineralizing perimeter and a respective 2- and 3-fold stimulation of the mineral appositional rate (MAR) and bone formation rate (BFR)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sixty-three 11-week-old virgin female Swiss-Webster mice[2].
Dosage: 80 μg/kg per day (hPTH).
Administration: S.C., 4 weeks (5 days a week).
Result: OVX osteoporotic mice respond to PTH by increased osteoblast activity and the consequent restoration of trabecular network.

分子量

4057.71

Formula

C180H291N55O48S2
CAS 号

98614-76-7
Sequence Shortening

AVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.