Katacalcin TFA;(Synonyms: PDN 21 TFA) 纯度: 99.18%
Katacalcin TFA (PDN 21 TFA) 是一种有效的具有降低血钙效应的多肽激素。
Katacalcin TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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500 μg | ¥1600 | In-stock | |
1 mg | ¥2600 | In-stock | |
5 mg | ¥9100 | In-stock | |
10 mg | ¥13000 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Katacalcin TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
Katacalcin TFA (PDN 21 TFA) is a potent plasma calcium-lowering peptide[1]. |
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体外研究 (In Vitro) |
Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones[1]. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14+ PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14+ PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
2550.62 |
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Formula |
C99H155F3N34O38S2 |
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Sequence |
Asp-Met-Ser-Ser-Asp-Leu-Glu-Arg-Asp-His-Arg-Pro-His-Val-Ser-Met-Pro-Gln-Asn-Ala-Asn |
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Sequence Shortening |
DMSSDLERDHRPHVSMPQNAN |
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中文名称 |
钙抑肽三氟乙酸盐 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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