Dynorphin A (1-10) (TFA); 纯度: 99.43%
Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽,与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流,IC50 为 42.0 μM。
Dynorphin A (1-10) (TFA) Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥1100 | In-stock | |
5 mg | ¥3600 | In-stock | |
10 mg | ¥5600 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
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Dynorphin A (1-10) (TFA) 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM. |
IC50 Target |
κ-opioid receptor[1] |
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体外研究 (In Vitro) |
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds in the transmembrane domain of the κ-receptor[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks INMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1348.48 |
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Formula |
C59H92F3N19O14 |
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Sequence |
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro |
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Sequence Shortening |
YGGFLRRIRP |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Sealed storage, away from moisture
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
DMSO : 100 mg/mL (74.16 mM; Need ultrasonic) H2O : 50 mg/mL (37.08 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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