Hoechst 34580 tetrahydrochloride;(Synonyms: HOE 34580 tetrahydrochloride) 纯度: 99.58%
Hoechst 34580 tetrahydrochloride是一种细胞渗透性的荧光染料,用于DNA和核染色。
Hoechst 34580 tetrahydrochloride Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | ; | Apply now | ; |
5 mg | ¥600 | In-stock | |
10 mg | ¥900 | In-stock | |
50 mg | ¥2400 | In-stock | |
100 mg | ¥3400 | In-stock | |
200 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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Hoechst 34580 tetrahydrochloride 相关产品
bull;相关化合物库:
- Neuronal Signaling Compound Library
- CNS-Penetrant Compound Library
- Anti-Alzheimer’s Disease Compound Library
- Neurodegenerative Disease-related Compound Library
- Bioactive Compound Library Plus
生物活性 |
Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei. |
IC50 Target |
Amyloid-β[1] |
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体外研究 (In Vitro) |
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
597.41 |
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Formula |
C27H33Cl4N7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4deg;C, sealed storage, away from moisture and light *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:;
H2O : 2.67 mg/mL (4.47 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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