Hoechst 34580 tetrahydrochloride(Synonyms: HOE 34580 tetrahydrochloride)

Hoechst 34580 tetrahydrochloride;(Synonyms: HOE 34580 tetrahydrochloride) 纯度: 99.58%

Hoechst 34580 tetrahydrochloride是一种细胞渗透性的荧光染料,用于DNA和核染色。

Hoechst 34580 tetrahydrochlorideamp;;(Synonyms: HOE 34580 tetrahydrochloride)

Hoechst 34580 tetrahydrochloride Chemical Structure

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Hoechst 34580 tetrahydrochloride 相关产品

bull;相关化合物库:

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生物活性

Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei.

IC50 Target

Amyloid-β[1]

体外研究
(In Vitro)

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

597.41

Formula

C27H33Cl4N7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

H2O : 2.67 mg/mL (4.47 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6739 mL 8.3695 mL 16.7389 mL
5 mM
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.