Hoechst 34580 tetrahydrochloride;(Synonyms: HOE 34580 tetrahydrochloride) 纯度: 99.58%
Hoechst 34580 tetrahydrochloride是一种细胞渗透性的荧光染料，用于DNA和核染色。
Hoechst 34580 tetrahydrochloride Chemical Structure
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Hoechst 34580 tetrahydrochloride is a cell-permeable fluorescent dye for staining DNA and nuclei.
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Room temperature in continental US; may vary elsewhere.
4deg;C, sealed storage, away from moisture and light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
H2O : 2.67 mg/mL (4.47 mM; Need ultrasonic)