Procion Blue HB;(Synonyms: 蓝色染料; Reactive Blue 2)
Procion Blue HB (Reactive Blue 2)是嘌呤能拮抗剂。
Procion Blue HB Chemical Structure
CAS No. : 12236-82-7
|10;mM;*;1 mL in DMSO||￥550||询问价格 货期|
|10 mg||￥500||询问价格 货期|
|50 mg||￥1500||询问价格 货期|
|100 mg||￥1900||询问价格 货期|
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Procion Blue HB 相关产品
- Anti-Cardiovascular Disease Compound Library
- Natural Product Like Compound Library
- Bioactive Compound Library Plus
Procion Blue HB (Reactive Blue 2) is a purinergic antagonist.
Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca2+-dependent manner and induce Ca2+ oscillations. The application of Reactive Blue 2 increases K+ secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a Ki of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
蓝色染料；普施安蓝 HB；活性蓝 2；汽巴蓝 F3GA
Room temperature in continental US; may vary elsewhere.
4deg;C, protect from light
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
DMSO : ≥ 110 mg/mL (142.09 mM)
H2O : 10 mg/mL (12.92 mM; Need ultrasonic)
Ethanol : < 1 mg/mL (insoluble)
* “≥” means soluble, but saturation unknown.