Procion Blue HB(Synonyms: 蓝色染料 Reactive Blue 2)

Procion Blue HB;(Synonyms: 蓝色染料; Reactive Blue 2)

Procion Blue HB (Reactive Blue 2)是嘌呤能拮抗剂。

Procion Blue HBamp;;(Synonyms: 蓝色染料; Reactive Blue 2)

Procion Blue HB Chemical Structure

CAS No. : 12236-82-7

规格 价格 是否有货
10;mM;*;1 mL in DMSO ¥550 询问价格 货期
10 mg ¥500 询问价格 货期
50 mg ¥1500 询问价格 货期
100 mg ¥1900 询问价格 货期

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Procion Blue HB 相关产品


  • Anti-Cardiovascular Disease Compound Library
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Procion Blue HB (Reactive Blue 2) is a purinergic antagonist.

(In Vitro)

Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca2+-dependent manner and induce Ca2+ oscillations[1]. The application of Reactive Blue 2 increases K+ secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion[2].The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a Ki of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing[3]. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2[4]. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.








蓝色染料;普施安蓝 HB;活性蓝 2;汽巴蓝 F3GA


Room temperature in continental US; may vary elsewhere.


4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

In Vitro:;

DMSO : ≥ 110 mg/mL (142.09 mM)

H2O : 10 mg/mL (12.92 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (insoluble)

* “≥” means soluble, but saturation unknown.

浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2917 mL 6.4586 mL 12.9172 mL
5 mM 0.2583 mL 1.2917 mL 2.5834 mL
10 mM 0.1292 mL 0.6459 mL 1.2917 mL


储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

  • [1]. Okuda A, et al. Reactive blue 2 induces calcium oscillations in HeLa cells. Jpn J Physiol. 2001 Jun;51(3):389-93.

    [2]. Lee JH, et al. Reactive blue 2, an antagonist of rat P2Y4, increases K+ secretion in rat cochlea strial marginal cells. Hear Res. 2006 Sep;219(1-2):66-73.

    [3]. Coughlan SJ, et al. Reactive blue 2 is a potent inhibitor of a thylakoid protein kinase. Eur J Biochem. 1991 Apr 23;197(2):467-71.

    [4]. Burnstock G, et al. P2-purinoceptors of two subtypes in the rabbit mesenteric artery: reactive blue 2 selectively inhibits responses mediated via the P2y-but not the P2x-purinoceptor. Br J Pharmacol. 1987 Feb;90(2):383-91.

    [5]. Uneyama H, et al. Suramin and reactive blue 2 are antagonists for a newly identified purinoceptor on rat megakaryocyte. Br J Pharmacol. 1994 Jan;111(1):245-9.