荧光染料Direct Violet 1(Synonyms: 直接青莲N；直接紫1；直接紫N)

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荧光染料Dye Reagents Direct Violet 1;(Synonyms: 直接青莲N；直接紫1；直接紫N)

Direct Violet 1 是一种偶氮染料，是一种纺织品染料。Direct Violet 1 还是一种 SARS-CoV-2 spike 蛋白与 ACE2 的蛋白-蛋白相互作用 (PPI) 的抑制剂，IC50 为 1.47-2.63 µM。

Direct Violet 1amp;;(Synonyms: 直接青莲N；直接紫1；直接紫N)

Direct Violet 1 Chemical Structure

CAS No. : 2586-60-9

规格 价格 是否有货 数量
10 mg ￥500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Direct Violet 1 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Antiviral Compound Library
  • Anti-Obesity Compound Library

生物活性

Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 µM[1][2].

IC50 Target

IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding)[1]
体外研究
(In Vitro)

Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC50 values of 1.47 µM, 2.63 µM, and 2.11 µM, respectively[1].
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC50 of 35.8 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

728.66

Formula

C32H22N6Na2O8S2
CAS 号

2586-60-9
中文名称

直接青莲N；直接紫1；直接紫N
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 62.5 mg/mL (85.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3724 mL 6.8619 mL 13.7238 mL
5 mM 0.2745 mL 1.3724 mL 2.7448 mL
10 mM 0.1372 mL 0.6862 mL 1.3724 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Damir Bojadzic, et al. Small-Molecule In Vitro Inhibitors of the Coronavirus Spike-ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2. bioRxiv, 2020 Oct 22.

    [2]. Wafaa M Abd El-Rahim, et al. Genotoxicity studies on the removal of a direct textile dye by a fungal strain, in vivo, using micronucleus and RAPD-PCR techniques on male rats. J Appl Toxicol. 2008 May;28(4):484-90.