荧光染料Trx-red(Synonyms: NBL-SS perchlorate)

荧光染料Dye Reagents Trx-red;(Synonyms: NBL-SS perchlorate) 纯度: 96.58%

Trx-red (NBL-SS perchlorate) 是衍生自尼罗蓝色荧光团的红色发射荧光探针。Trx-red 用于在活细胞和体内选择性地对硫氧还蛋白 (thioredoxin, Trx) 成像 (λex=615 nm, λem=661 nm)。

Trx-red(Synonyms: NBL-SS perchlorate)

Trx-red Chemical Structure

CAS No. : 2368978-96-3

规格 价格 是否有货 数量
5 mg ¥3500 In-stock
10 mg ¥5800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Trx-red 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Covalent Screening Library

生物活性

Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derivatized from the nile blue fluorophore. Trx-red is used for selectively imaging thioredoxin (Trx) in live cells and in vivo (λex=615 nm, λem=661 nm)[1].

体外研究
(In Vitro)

Trx-red (NBL-SS) displayed multiple favorable properties, such as red emission, fast response, and high fluorescence signal. Thioredoxin (Trx) is a ubiquitous redox-regulating protein essentially involved in cell growth, differentiation, and death[1].
When HeLa cells are incubated with Trx-red (NBL-SS; 5 μM; 0-30 min), a clear time-dependent increase of the fluorescence is observed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Trx-red (NBL-SS; 10 μM; 30 min) is also suitable to image thioredoxin in 6 day-old zebrafish larvae[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

714.16

Formula

C29H32ClN3O12S2

CAS 号

2368978-96-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

DMSO : 50 mg/mL (70.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4002 mL 7.0012 mL 14.0025 mL
5 mM 0.2800 mL 1.4002 mL 2.8005 mL
10 mM 0.1400 mL 0.7001 mL 1.4002 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Huiyi Jia, et al. Fluorophore-Dependent Cleavage of Disulfide Bond Leading to a Highly Selective Fluorescent Probe of Thioredoxin. Anal Chem. 2019 Jul 2;91(13):8524-8531.