Photo-lysine(Synonyms: Photo lysine)

生化分析试剂 Biochemical Assay Reagents
Photo-lysine;(Synonyms: Photo lysine)

Photo-lysine,一种新的基于赖氨酸光反应性的氨基酸,它捕获结合赖氨酸翻译后修饰的蛋白质。

Photo-lysine(Synonyms: Photo lysine)

Photo-lysine Chemical Structure

CAS No. : 1863117-91-2

规格 价格 是否有货
5 mg ¥12000 询问价格 货期
10 mg ¥21600 询问价格 货期
20 mg ¥36000 询问价格 货期

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Photo-lysine 的其他形式现货产品:

Photo-lysine hydrochloride

生物活性

Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.

体外研究
(In Vitro)

Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ‘readers’ and ‘erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

172.19

Formula

C6H12N4O2

CAS 号

1863117-91-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang T, et al. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2.