Hesperidin(Synonyms: 橙皮苷; Hesperetin 7-rutinoside)

天然产物 糖类和糖苷 Saccharides and Glycosides

Hesperidin;(Synonyms: 橙皮苷; Hesperetin 7-rutinoside) 纯度: 99.19%

Hesperidin (Hesperetin 7-rutinoside) 是一种广泛存在于柑橘类水果中黄烷酮糖苷。Hesperidin 具有多种生物学特性,例如减少炎症介质并发挥重要的抗氧化作用。Hesperidin 还表现出抗肿瘤和抗过敏活性。

Hesperidin(Synonyms: 橙皮苷; Hesperetin 7-rutinoside)

Hesperidin Chemical Structure

CAS No. : 520-26-3

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ¥550 In-stock
10 mg ¥500 In-stock
50 mg ¥900 In-stock
100 mg ¥1200 In-stock
200 mg ¥1600 In-stock
500 mg ¥1900 In-stock
1 g ¥2900 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

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生物活性

Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities[1][2].

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Hesperidin (5-200 µM; 24-72 h) induces potent cytotoxic effects in human osteosarcoma MG-63 cells[1].
Hesperidin (5-150 µM; 48 h) induces early and late apoptosis in MG-63 cells[1].
Hesperidin (10-30 µM) inhibits the activity of COX-2 and iNOS in a dose dependent manner in RAW 264.7 cells activated with LPS[2].
Hesperidin (0.1 μg/mL; 2 h) decreases the formation of MDA and intracellular ROS, including chondrocyte apoptosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MG-63 cells
Concentration: 0, 5, 25, 50, 100, 150, 200 µM
Incubation Time: 24, 48, 72 hours
Result: Led to time-dependent and concentration-dependent cytotoxic effects, with IC50s of 94.3, 78.6 and 63.3 µM at 24, 48 and 72 h, respectively.

Apoptosis Analysis[1]

Cell Line: MG-63 cells
Concentration: 0, 5, 50, 150 µM
Incubation Time: 48 hours
Result: Increased the percentage of apoptotic cells from 4.7% to 17.9, 34.6 and 68.3% at the concentration of 0, 5, 50 and 150 µM, respectively.

体内研究
(In Vivo)

Hesperidin (5-80 mg/kg; 2 weeks) significantly suppresses MG-63 tumor growth in mice[1].
Hesperidin (200 mg/kg; once daily for 28 d) markedly attenuates cartilage destruction and reduces IL-1β and TNF-α levels in a surgically-induced osteoarthritis (OA) rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

610.56

Formula

C28H34O15

CAS 号

520-26-3

中文名称

橙皮苷;橙皮甙

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 33 mg/mL (54.05 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6378 mL 8.1892 mL 16.3784 mL
5 mM 0.3276 mL 1.6378 mL 3.2757 mL
10 mM 0.1638 mL 0.8189 mL 1.6378 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.09 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.09 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Du GY, et, al. Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial-mediated apoptosis. Oncol Lett. 2018 Nov;16(5):6299-6306.

    [2]. Tejada S, et, al. Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus. Curr Med Chem. 2018;25(37):4929-4945.

    [3]. Gao G, et, al. Effects of Hesperidin on H₂O₂-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model. Med Sci Monit. 2018 Dec 17;24:9177-9186.

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