Rutin(Synonyms: 芦丁; Rutoside; Quercetin 3-O-rutinoside)

天然产物 糖类和糖苷 Saccharides and Glycosides

Rutin;(Synonyms: 芦丁; Rutoside; Quercetin 3-O-rutinoside) 纯度: ge;98.0%

Rutin (Rutoside) 是一种广泛存在于多种植物中的黄酮类化合物,具有抗炎、降糖、抗氧化、神经保护、肾脏保护、肝脏保护和降低Aβ低聚物活性等多种生物活性。Rutin 能穿过血脑屏障。Rutin 通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。

Rutin(Synonyms: 芦丁; Rutoside;  Quercetin 3-O-rutinoside)

Rutin Chemical Structure

CAS No. : 153-18-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ¥500 In-stock
500 mg ¥400 In-stock
5 g ¥500 In-stock
10 g ¥700 In-stock
50 g ; 询价 ;

* Please select Quantity before adding items.

Rutin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • CNS-Penetrant Compound Library
  • Autophagy Compound Library
  • Anti-Aging Compound Library
  • Drug Repurposing Compound Library
  • Diabetes Related Compound Library
  • Glycoside Compound Library
  • Oxygen Sensing Compound Library
  • Anti-COVID-19 Compound Library
  • NMPA-Approved Drug Library
  • Phenols Library
  • Orally Active Compound Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Flavonoids Library
  • Anti-Alzheimer’s Disease Compound Library
  • Neuroprotective Compound Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food Additive Library
  • Food-Sourced Compound Library

生物活性

Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress[1][2][3].

体内研究
(In Vivo)

Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signaling[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

610.52

Formula

C27H30O16

CAS 号

153-18-4

中文名称

芦丁;芸香甙;维生素 P;紫槲皮甙;路丁;路丁粉;络通;紫皮甙

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 50 mg/mL (81.90 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6379 mL 8.1897 mL 16.3795 mL
5 mM 0.3276 mL 1.6379 mL 3.2759 mL
10 mM 0.1638 mL 0.8190 mL 1.6379 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.09 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.09 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.

    [2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

    [3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.

    [4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.

发表回复