Niazinin

天然产物 糖类和糖苷 Saccharides and Glycosides

Niazinin;

Niazinin 是一种硫代氨基甲酸酯糖苷,具有抗利什曼原虫活性,IC50 值为 5.25 μM。Niazinin 还显示出与目标蛋白 3CL 蛋白酶的结合亲和力。Niazinin 具有杀利什曼原虫、抗炎和解热活性。

Niazinin

Niazinin Chemical Structure

CAS No. : 147821-57-6

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生物活性

Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC50 value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity[1][2].

体外研究
(In Vitro)

Niazinin, is cytotoxic at substantially higher concentration (CC50 of 31.6 µM) than its antileishmanial concentration (IC50 of 5.25 µM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

343.40

Formula

C15H21NO6S

CAS 号

147821-57-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Amandeep Kaur, et al. Antileishmanial compounds from Moringa oleifera Lam. Z Naturforsch C J Biosci. Mar-Apr 2014;69(3-4):110-6.

    [2]. Shiv Rakesh Naik, et al. Structure-based virtual screening, molecular dynamics and binding affinity calculations of some potential phytocompounds against SARS-CoV-2. J Biomol Struct Dyn. 2021 Mar 8;1-18.