Rhein-8-glucoside calcium(Synonyms: 大黄酸-8-O-β-D-葡萄糖苷)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Rhein-8-glucoside calcium;(Synonyms: 大黄酸-8-O-β-D-葡萄糖苷)

Rhein-8-glucoside calcium，一种从 Saussurea lappa 根的 EtOH 提取物中分离得到的蒽醌化合物。Rhein-8-glucoside calcium 是一种 hPTP1B 抑制剂，IC50 值为11.5 μM。Rhein-8-glucoside calcium 具有抗菌作用。

Rhein-8-glucoside calcium(Synonyms: 大黄酸-8-O-β-D-葡萄糖苷)

Rhein-8-glucoside calcium Chemical Structure

CAS No. : 113443-70-2

规格 是否有货
5 mg 询价
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25 mg 询价

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生物活性

Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC50 of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects[1][2].

IC50 Target

IC50: 11.5 μM (hPTP1B)[1]
分子量

484.42

Formula

C21H16CaO11
CAS 号

113443-70-2
中文名称

大黄酸-8-O-β-D-葡萄糖苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li S, et, al. PTP1B inhibitors from Saussrurea lappa. J Asian Nat Prod Res. Apr-May 2006;8(3):281-6.

    [2]. Zhang Y, et, al. Effects of Rhein-8-O-β-D-glucopyranoside on the Biofilm Formation of Streptococcus mutans. Curr Microbiol. 2020 Oct 31.

    [3]. Zhang LS, et, al. Rhein-8-O-β-D-glucopyranoside inhibited high glucose-induced apoptosis of human mesangial cells by regulating the lincRNA ANRIL/let-7a/TGF-β1/Smad signaling pathway. Exp Ther Med. 2020 Apr;19(4):2871-2878.