Chitobiose

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Chitobiose;

Chitobiose 是一种壳寡糖，是 β-1,4-氨基葡萄糖的二聚体。Chitobiose 具有口服活性和较高的抗氧化活性。

Chitobiose

Chitobiose Chemical Structure

CAS No. : 577-76-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units[1]. Chitobiose has orally activity and high antioxidant activity[2].

体内研究
(In Vivo)

Chitobiose (30, 100, 300 mg/kg; p.o., single) can enters the circulatory system when given orally[2].
Pharmacokinetic Parameters of Chitobiose in Wistar strain male rats[2].

PO (30 mg/kg) PO (100 mg/kg) PO (300 mg/kg)
Tmax (h) 0.9 1.0 1.8
Cpmax (μg/mL) 1.1 4.4 6.9
AUC0-4h (μg·h/mL) 2.5 9.0 17.6
AUMC0-4h (μg·h^2/mL) 4.0 13.2 35.6
MRT (h) 1.6 1.5 1.6
MAT (h) 1.1 1.0 1.2
ka (h^-1) 0.95 0.99 0.96
F1-4h (%) 1.8 2.0 1.3

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar strain male rats (7 weeks, 165-185 g)[2]
Dosage: 30, 100, 300 mg/kg
Administration: p.o., single (Pharmacokinetics analysis)
Result: Entered the circulatory system when given orally.

分子量

340.33

Formula

C12H24N2O9
CAS 号

577-76-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020;2020:2394704. Published 2020 Apr 11.

    [2]. Chen AS, Taguchi T, Okamoto H, et al. Pharmacokinetics of chitobiose and chitotriose administered intravenously or orally to rats. Biol Pharm Bull. 2005;28(3):545-548.