1-Deoxynojirimycin hydrochloride(Synonyms: Duvoglustat hydrochloride)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

1-Deoxynojirimycin hydrochloride;(Synonyms: Duvoglustat hydrochloride)

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) 是一种口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂。1-Deoxynojirimycin hydrochloride 抑制餐后血糖，预防糖尿病。1-Deoxynojirimycin hydrochloride 具有降血糖、减肥和抗病毒的作用。

1-Deoxynojirimycin hydrochloride(Synonyms: Duvoglustat hydrochloride)

1-Deoxynojirimycin hydrochloride Chemical Structure

CAS No. : 73285-50-4

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生物活性

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

体内研究
(In Vivo)

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect [3].
1-Deoxynojirimycin hydrochloride significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[3]
Dosage: 20, 40, 80 mg/kg
Administration: Intravenously; daily for four weeks
Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.

Clinical Trial

分子量

199.63

Formula

C6H14ClNO4
CAS 号

73285-50-4
中文名称

去氧野艽霉素盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.

    [2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT – Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232.

    [3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14.