Soyasaponin II

天然产物 糖类和糖苷 Saccharides and Glycosides

Soyasaponin II  纯度: 99.81%

Soyasaponin II 是具有抗病毒活性的皂苷。Soyasaponin II 抑制 HSV-1,HCMV,流感病毒和 HIV-1 的复制。Soyasaponin II 对 HSV-1 复制显示出有效的抑制作用。Soyasaponin II 作为 YB-1 磷酸化和 NLRP3 炎性小体引发的抑制剂,可保护小鼠免受 LPS/GalN 诱导的急性肝衰竭。

Soyasaponin II

Soyasaponin II Chemical Structure

CAS No. : 55319-36-3

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1 mg ¥1500 In-stock
5 mg   询价  
10 mg   询价  

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生物活性

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].

IC50 & Target[1][2]

HSV-1

54 μM (IC50)

HIV-1

112 μM (IC50)

influenza virus

88 μM (IC50)

HCMV

104 μM (IC50)

NLRP3 inflammasome

 

体外研究
(In Vitro)

Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

913.10

Formula

C47H76O17

CAS 号

55319-36-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Hayashi K, et al. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 1997;63(2):102-105.

    [2]. Wang F, et al. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics. 2020;10(6):2714-2726. Published 2020 Feb 3.