天然产物 天然产物苯丙素类 Phenylpropanoids
Yangambin 纯度: ≥98.0%
Yangambin 是一种呋喃木脂素 (furofuran lignan)，已经从诸如番荔枝科 (Annonaceae family) 的植物中分离出来，包括：R. pickeli，R. exalbida 和 R. mucosa 以及 Magnolia biondii。 Yangambin 是一种选择性 PAF 受体拮抗剂，通过调控 Ca2+ 通道抑制 Ca2+ 流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少。Yangambin 表现出对 β-氨基己糖苷酶 (β-hexosaminidase) 的抗过敏活性，IC50 为 33.8 μM，抗炎活性的 IC50 为 37.4 μM。
Yangambin Chemical Structure
CAS No. : 13060-14-5
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 5 mg | ￥8800 | In-stock | |
| 10 mg | ￥15000 | In-stock | |
| 50 mg | 询价 | ||
| 100 mg | 询价 |
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Yangambin 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
| 生物活性 |
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2]. |
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| IC50 & Target[1] |
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| 分子量 |
446.49 |
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| Formula |
C24H30O8 |
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| CAS 号 |
13060-14-5 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 参考文献 |
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