Licarin A(Synonyms: (+)-Licarin A)

发表于由

天然产物 天然产物苯丙素类 Phenylpropanoids

Licarin A (Synonyms: (+)-Licarin A) 纯度: 98.16%

Licarin A ((+)-Licarin A) 显着降低二硝基苯肼-人血清白蛋白 (DNP-HSA) 刺激的 RBL-2H3 细胞。具有抗过敏作用。Licarin A 降低 TNF-α 和 PGD2 产生，和 COX-2 表达。

Licarin A(Synonyms: (+)-Licarin A)

Licarin A Chemical Structure

CAS No. : 51020-86-1

规格 价格 是否有货 数量
1 mg ￥1300 In-stock
5 mg ￥3200 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Licarin A 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • GPCR/G Protein Compound Library
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Anti-Aging Compound Library
  • Differentiation Inducing Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Angiogenesis Related Compound Library

生物活性

Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1].

体外研究
(In Vitro)

Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1].
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

326.39

Formula

C20H22O4
CAS 号

51020-86-1
中文名称

里卡灵 A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Takuya Matsui, et al. Licarin A Is a Candidate Compound for the Treatment of Immediate Hypersensitivity via Inhibition of Rat Mast Cell Line RBL-2H3 Cells. J Pharm Pharmacol. 2015 Dec;67(12):1723-32.