天然产物 天然产物苯丙素类 Phenylpropanoids
Praeruptorin B (Synonyms: Praeruptorin D) 纯度: 99.95%
Praeruptorin B 是固醇调控元件结合蛋白 (SREBPs) 的抑制剂。
Praeruptorin B Chemical Structure
CAS No. : 73069-28-0
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥1500 | In-stock | |
10 mg | ¥2400 | In-stock | |
25 mg | ¥4800 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Praeruptorin B 相关产品
•相关化合物库:
- Natural Product Library Plus
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- Traditional Chinese Medicine Monomer Library
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- Anti-Obesity Compound Library
- Lipid Metabolism Compound Library
生物活性 |
Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). |
IC50 & Target |
SREBP[1]. |
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体外研究 (In Vitro) |
Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2[1]. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
426.46 |
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Formula |
C24H26O7 |
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CAS 号 |
73069-28-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 25 mg/mL (58.62 mM; ultrasonic and warming and heat to 60°C) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 MCE 网站选购。
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参考文献 |
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Cell Assay [1] |
HepG2 cells and HL-7702 cells are used in the study. Cell proliferation is determined by the MTT assays. The HepG2 cells are seeded in 96-well plates with 2.0×104 cells per well in DMEM containing 10% FBS for 24 h. Cells are further treated with Praeruptorin B (0, 2.5, 5, 10, 20, 40, 80 μM) for 18 h[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
Mice[1] MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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