6-Hydroxyrubiadin

天然产物 天然产物苯丙素类 Phenylpropanoids

6-Hydroxyrubiadin 

6-Hydroxyrubiadin 是一种天然的蒽酮,是用于炎症和炎症性疾病研究的候选化合物。

6-Hydroxyrubiadin

6-Hydroxyrubiadin Chemical Structure

CAS No. : 87686-86-0

规格 是否有货
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生物活性

6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases[1].

体外研究
(In Vitro)

6-hydroxyrubiadin suppresses lipopolysaccharide (LPS)-induced nuclear factor-kappa B activation as well as the phosphorylation of c-Jun N-terminal kinase in RAW 264.7 macrophages[1].
6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-a, interleukin (IL)-1b and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

270.24

Formula

C15H10O5

CAS 号

87686-86-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yanting Wu, et al. In vitro and in vivo inhibitory effects of 6-hydroxyrubiadin on lipopolysaccharide-induced inflammation. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):107-116.