(+)-Medicarpin(Synonyms: (+)-美迪紫檀素)

天然产物 黄酮类 Flavonoids

(+)-Medicarpin (Synonyms: (+)-美迪紫檀素)

(+)-Medicarpin 是一种异黄酮,可以从具有各种生物学效应的几种药用植物中分离出来,包括槐花,Zollernia paraensisPlatymiscium yucatamunMachaerium aristulatumPlatymiscium floribundum 等。(+)-Medicarpin 有效抑制破骨细胞生成,它还通过雌激素受体 β (ERβ) 介导的成骨作用的成骨细胞分化促进骨愈合并增加骨量。

(+)-Medicarpin(Synonyms: (+)-美迪紫檀素)

(+)-Medicarpin Chemical Structure

CAS No. : 33983-39-0

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生物活性

(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action[1].

IC50 & Target[1]

ERβ

 

分子量

270.28

Formula

C16H14O4

CAS 号

33983-39-0

中文名称

(+)-美迪紫檀素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang X, et al. Total Synthesis of (+)-Medicarpin. J Nat Prod. 2017 Dec 22;80(12):3284-3288.