Tilianin(Synonyms: 田蓟苷)

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天然产物 黄酮类 Flavonoids

Tilianin (Synonyms: 田蓟苷) 纯度: 99.57%

Tilianin 是一种活性黄酮类苷，广泛存在于多种药用植物中，具有降压、保护心肌、抗糖尿病、降血脂、抗炎、抗氧化等作用。

Tilianin(Synonyms: 田蓟苷)

Tilianin Chemical Structure

CAS No. : 4291-60-5

规格 价格 是否有货 数量
5 mg ￥2020 In-stock
10 mg ￥3430 In-stock
50 mg   询价  
100 mg   询价  

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Tilianin 相关产品

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生物活性

Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects[1][2][3].

体外研究
(In Vitro)

Tilianin (10 μM, 20 μM) reduced secretion of LPS (1 μg/mL)-induced proinflammatory cytokine in RAW264.7 macrophage cell[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Tilianin (10 mg/kg; i.p.) is a potential agent for ameliorating LPS-induced acute lung injury (ALI)[2].
Tilianin shows Tmax=10.8 min, Cmax=176.9 nmol/L, AUC0-∞= 17.4 min*μmol/L in mice[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mouse[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection
Result: Attenuated infiltration of macrophages and histopathological changes and improved inflammation.
Animal Model: Male FVB mice (6-10 weeks) [3]
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: Oral gavage
Result: Tmax(10.8 min), Cmax(176.9 nmol/L), AUC0-∞ (17.4 min*μmol/L).

分子量

446.40

Formula

C22H22O10
CAS 号

4291-60-5
中文名称

田蓟苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (112.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2401 mL 11.2007 mL 22.4014 mL
5 mM 0.4480 mL 2.2401 mL 4.4803 mL
10 mM 0.2240 mL 1.1201 mL 2.2401 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.66 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.66 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.66 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.66 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Sergienko TO, et al. Moldavoside–new flavonoid glycoside of Dragocephalum moldavicum L. Farm Zh. 1968;23(2):75-8.

    [2]. Yonghong Zhang , et al. Role of Tilianin against Acute Lung Injury in In Vitro LPS-Induced Alveolar Macrophage Cells and an In Vivo C57BL/6 Mice Model. J Environ Pathol Toxicol Oncol. 2020;39(4):335-344.

    [3]. Liping Wang, et al. Simultaneous determination of tilianin and its metabolites in mice using ultra-high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. Biomed Chromatogr. 2018 Apr;32(4).