天然产物 黄酮类 Flavonoids
Sciadopitysin (Synonyms: 金松双黄酮) 纯度: 99.17%
Sciadopitysin 是一种来自银杏叶片中的双黄酮类化合物。Sciadopitysin 通过抑制 NF-κB 活化并降低 c-Fos 和 NFATc1 的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。
Sciadopitysin Chemical Structure
CAS No. : 521-34-6
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥1190 | In-stock | |
10 mg | ¥2020 | In-stock | |
20 mg | ¥3430 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Sciadopitysin 相关产品
•相关化合物库:
- Natural Product Library Plus
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- NF-κB Signaling Compound Library
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生物活性 |
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2]. |
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IC50 & Target[2] |
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体外研究 (In Vitro) |
Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
580.54 |
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Formula |
C33H24O10 |
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CAS 号 |
521-34-6 |
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中文名称 |
金松双黄酮 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 20 mg/mL (34.45 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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